Endocrine Abstracts

Background: Down Syndrome (DS) is the most common chromosomal abnormality. Obesity and type 1 diabetes mellitus (T1DM) are known to be more prevalent in patients with DS than the general population. Available data on the prevalence of type 2 diabetes mellitus (T2DM) in DS is scant.Objectives: This study aims to investigate the prevalence of obesity and diabetes mellitus (DM) in adults with DS seen in Imperial College London Diabetes Centre (ICLDC) in the...

Covid-19 infection severity has been associated with pre-existing conditions including obesity. Individuals with Down Syndrome (DS) are potentially at high risk. Reports on the outcomes of Covid-19 infection in individuals with DS are scant. Here we present such a case. MA is a 27-year old Emirati male with DS, obesity and hypothyroidism. He was brought to the ER with a history of hemoptysis (2 days), fever and cough (1 week). He tested positive for Covid-19. Initial investiga...

Background: Type 2 diabetes (T2D) and obesity have been linked with sleeping disorders in general and obstructive sleep apnoea (OSA) in particular; both are highly prevalent amongst Emirati patients. However, little information is available in this population regarding the prevalence and symptomatology of OSA, its relationships with T2D and obesity, and its impact on health outcomes.Objectives: This study aims to investigate the risk of OSA based on the ...

Background: Efficacy of bariatric surgery (BS) in obesity management is well-established. The super-obese (BMI >50 kg/m2) as a subgroup may have specific phenotypic and genotypic characteristics. Prevalence of complications and risks of interventions may also be different in this group.Aims: We have investigated BS outcomes and compared effects of different operations among the superobese in an Emirati population.Methods...

IntroductionMelanocortin-4-receptor (MC4R) deficiency is the commonest of the rare monogenic forms of obesity. Bariatric surgery (BS) is the most efficacious treatment modality in the more ’common’ polygenic obesity. Effect of surgical and drug treatment in obesity due to MC4R deficiency is not well-established.AimWe aimed to explore the effects of BS and drug treatment among the confirmed cases of ...